Posted By Bonnie on September 10, 2009
Below is a sneak preview of the first chapter of my new book for Lucent’s Disorders and Diseases series, Thyroid Disorders. Enjoy!
Chapter 1
The Body’s Thermostat
Imagine a swimmer diving into a pool on a warm day. Before diving into the pool, the swimmer may have felt warm or even hot. But the water in the pool is cooler than the temperature of the swimmer’s body. The swimmer quickly cools off and may even begin to feel cold. After some time has passed, though, the swimmer acclimates – the body seems to get used to the cool water and the swimmer warms up.
The process of warming up a cold body may seem simple. But it isn’t. The body does not just “get used to” the temperature of the water in a cold pool. First the body must send messages to the brain, explaining that the temperature is dropping. The brain constantly monitors messages from the body related to temperature, because the human body functions best within a certain temperature range. When the brain receives messages saying that the body is getting too cold, it takes action. It sends a message to the thyroid gland. The thyroid gland can release chemicals that will stimulate the body’s metabolism and produce heat – if the thyroid is healthy. If not, the swimmer may find the cold water in the pool difficult to tolerate.
The Butterfly Gland
The thyroid gland may seem like a small organ to have such an important job. It is fairly small, about the size of an egg, and weighs less than three quarters of an ounce. It is located at the front of the throat, just below the larynx, or voicebox, and is wrapped around the windpipe on three sides. The thyroid is a light purple-red in color, and is shaped like a butterfly. The middle of the thyroid is called the isthmus, and there are two to three inch long rubbery “wings” on either side.
When the thyroid gland is healthy, most people never even think about it. If it gets infected, a doctor may be able to feel swelling in the neck (this is different from the swelling of lymph glands in the neck, which a doctor may also find swollen when the body is fighting off an infection).
The Endocrine System
The thyroid gland takes its instructions from the brain. The brain has two ways to send instructions to other parts of the body. It can send electrical impulses through the nervous system, telling muscles to relax and contract. But the brain also has another message delivery system too: the endocrine system. The endocrine system uses chemicals called hormones to carry messages to the body’s cells. Hormones are produced by glands that are located all over the body. For example, the thyroid gland is in the throat, and the adrenal glands are nestled on top of the kidneys. The glands of the endocrine system are not connected to each other physically. They must use hormones to communicate with each other, as well as with the body’s cells. After the glands produce hormones, they release the hormones into the bloodstream, and the blood carries the hormones throughout the body.
As hormones travel through the body, they touch many different cells. Certain cells have receptors, places where the hormone can connect to the cell and stimulate it to take different actions. If a cell does not have a receptor for a particular hormone, the hormone passes it by and continues to travel through the body. If the cell does have a receptor, the hormone binds to it. Then it stimulates the cell to do certain things. For example, it might stimulate a cell to make a particular protein, or to make an enzyme. Some doctors compare cell receptors and hormones to locks and keys. Each key, or hormone, can only interact with a certain kind of cell receptor, or lock.
The glands of the endocrine system are not physically connected to each other, but, at the base of the brain, they are connected to the nervous system. The connection is located in a gland called the hypothalamus. The hypothalamus is located in the middle of the brain. It receives information from sensory organs, such as the skin. It also produces hormones that tell the body’s glands what hormones they should release.
The Thyroid in Action
Consider the example of the swimmer who jumped into a cold pool. The skin contains special cells, called thermoreceptors, whose job it is to monitor the skin’s temperature. When the skin becomes cold, the thermoreceptors send an electrical impulse through the nervous system to the hypothalamus. In response, the hypothalamus releases a chemical known as TRH (TSH-releasing hormone). The TRH travels through several short blood vessels to the pituitary gland, a gland just below the hypothalamus in the middle of the brain. The TRH binds to receptors on cells in the pituitary gland, stimulating them to produce another hormone, TSH (thyroid-stimulating hormone).
After the pituitary releases TSH, the TSH travels through the bloodstream to the neck. It enters the thyroid, and binds to receptors on thyroid cells. There it stimulates them to release thyroxine, a hormone that causes cells to speed up and become more active. The cells begin to use more nutrients, breaking the nutrients down into energy. The range of processes that take place as the body’s cells break down oxygen and calories to make energy is called the metabolism. As the cells become more active, they produce heat, and the body’s temperature increases. That is why people who tend to be warm all the time often say that their bodies have a faster metabolism.
Because the body has become warmer, thermoreceptors in the skin stop sending signals to the hypothalamus saying that the body is cold. By now the swimmer feels warm, or at least comfortable, in the pool. He or she has become used to the temperature of the water. All this is possible because the swimmer’s endocrine system, especially the thyroid gland, is strong and healthy. People whose overall health, including the health of the endocrine system, has been weakened by a cold or flu, or by age, may have a harder time adjusting to cold water in a pool, or to cold outdoor temperatures in the winter. Likewise, difficulty coping with cold or warm temperatures is one of the most common symptoms of a thyroid disorder. The thyroid is so important in the regulation of the body’s temperature that many people call it the body’s thermostat.
If the water starts to get colder, the body’s feedback loop of thermoreceptors to hypothalamus to pituitary to thyroid to the body’s cells may be triggered again. The brain constantly monitors conditions in the body, and reacts when conditions, such as temperature, become unfavorable. The hypothalamus and pituitary continually adjust and readjust the amounts of hormones that they release, trying to keep the body’s temperature consistently within a certain range.
The Thyroid’s Job Description
Regulating the body’s temperature is just one of the thyroid’s functions in the body. Hormones released by the thyroid affect every cell in the body. Why? The thyroid gland governs the body’s metabolism. Metabolism refers to all of the processes used by the body to generate and use energy. Every system in the body uses energy, so every system in the body has to make energy or convert it from some other substance.
All the cells in the human body must go through the same basic process to get energy. The digestive system breaks food down into tiny molecules of sugar, such as glucose. Cells use glucose to make energy. But they need more than just glucose. They also need oxygen. They also need their own genes to tell them how to convert glucose and oxygen to energy. That is why thyroid hormones are so important. When a cell encounters thyroid hormones, it takes the thyroid hormones into its nucleus. The nucleus contains the cell’s genes, and some of those genes have receptors for thyroid hormones. The thyroid hormones stick to those receptors, turning some genes on and other genes off. By doing so, the hormones control the speed at which the cell metabolizes energy.
When doctors and biologists talk about the body’s metabolism, they mean all of the processes that relate to how the body gets energy: eating and digesting food, eliminating waste, breathing, circulation, the functioning of the brain and the nervous system, and the conversion of nutrients and oxygen to energy by the body’s cells. Thyroid hormones control the speed at which all those processes occur. The thyroid can slow all the body’s processes down or speed them all up. It affects the rate at which the heart beats, and the speed of digestion. It even determines the speed of operations in the brain – which means that a healthy thyroid can make a big difference in how fast a person thinks, talks, and works. It also affects people’s weight. People with less active thyroids have slower metabolisms and tend to gain weight easily. People with more active thyroids tend to have faster metabolisms and have a harder time gaining weight.
Growth and Development
By controlling the metabolism, the thyroid also governs growth and development. It can cause a developing child to grow more quickly or more slowly than normal. As a result, having a healthy thyroid gland is especially important for babies and children. Children with healthy thyroids grow at a normal pace and hit their developmental milestones at regular intervals. Children with thyroid disorders, however, may not develop normally. They may be much smaller than other children of the same age, or much taller. If a woman has a thyroid disorder during pregnancy, her baby may not develop properly and may be born with birth defects or brain damage. Babies who develop thyroid disorders after birth are at risk for mental retardation, and the damage is often permanent. Sometimes the damage is not as severe, and in these cases, babies and children with hypothyroidism may end up with milder developmental delays or learning disabilities. Hypothyroidism can also affect the onset of puberty, causing it to be delayed or to start several years early.
Hormones relating to growth and development affect adults too. They stimulate the formation of new cells and tissue in the heart, brain, eyes, skin, muscle, bone, liver, kidneys, and intestines. They also stimulate the body’s cells to reproduce themselves when necessary to repair damaged or infected tissues.
Recognizing Thyroid Disorders
Most primary care doctors have not been trained to recognize thyroid disorders. One study showed that doctors in HMOs (Health Management Organizations) accurately diagnose thyroid disorders in fewer than 50 percent of their depressed patients. (Depression, like fatigue and intolerance of hot and cold, is a common symptom of thyroid patients.) However, lack of training is not the only obstacle that doctors face when trying to diagnose a thyroid disorder. Because thyroid hormones affect the entire body, symptoms of a thyroid disorder can show up in any of the body’s organs and organ systems. A person with a thyroid disorder may have symptoms that, to a doctor, seem vague, random and unrelated to each other. The doctor may suspect that nothing is wrong with the patient at all and that the disorder, if there is one, is entirely mental or emotional.
Another obstacle to getting a diagnosis is that people with thyroid disorders may not realize themselves that anything is wrong. The symptoms of thyroid disorders tend to be things like fatigue, weight gain or loss, a tendency to feel too hot or too cold, dry skin, constipation, and anxiety or irritability. Patients often blame themselves and their lifestyles for symptoms such as fatigue and changes in weight. Rather than talk to a doctor, they may try to address the symptoms themselves by getting more rest, eating healthfully, and exercising. If lifestyle changes do not work, patients may blame themselves, thinking that they did not make enough of a change or did not try hard enough.
Screening for Thyroid Disorders
Because it is so hard to diagnose thyroid disorders based on the symptoms, some doctors are taking the approach of routinely ordering a blood test to check the thyroid hormone levels of patients who fall into certain categories. For instance, newborns are always checked for hypothyroidism, not because they are at more risk, but because untreated hypothyroidism is so dangerous for babies.
Some doctors ask about a family history of thyroid disorders and autoimmune disorders when they take an adult patient’s medical history. If there is a family history of thyroid disease, doctors may plan to check for it periodically even if the patient has not mentioned any symptoms. People who have a family history of thyroid disease or a family history of an autoimmune disorder such as diabetes, lupus, or rheumatoid arthritis are more at risk for developing thyroid disorders themselves. About half of patients whose parents have thyroid disorders will develop a thyroid disorder too.
Many gynecologists also routinely order thyroid panels as part of their annual checkup for women over the age of 30, knowing that women are much more likely to develop thyroid disorders than men, and that a woman’s chances of developing a thyroid disorder increase with age. Some psychiatrists also routinely check thyroid function in their patients, since thyroid disorders are a common cause of depression, anxiety, and other mood disorders. Once the possibility of a thyroid disorder has been raised, it is much easier for doctors to diagnose it.
Blood Tests
Doctors used to diagnose thyroid disorders based on a patient’s medical history and symptoms. But now it is possible to test a patient’s blood for thyroid hormones. Many doctors feel that the most sensitive blood test for thyroid disease is a TSH test – a test of the levels of thyroid stimulating hormone released by the pituitary gland.
A blood test can show the levels in the blood of hormones that were made by the thyroid. This kind of blood test checks for thyroxine, called T4, and for triiodothyronine, called T3. (These hormones are called T3 and T4 because they contain iodine atoms – three iodine atoms in T3 and four in T4). Tests of T3 and T4 can be used as a way to follow up on an abnormal TSH result or to help a doctor interpret an abnormal TSH result.
Patients who have an underactive thyroid, or hypothyroidism, will normally have higher than average levels of TSH in their blood, because the pituitary releases more and more TSH in an attempt to stimulate an underactive thyroid. In these cases, a doctor would expect to see low levels of T3 and T4. On the other hand, patients who have an overactive thyroid, or hyperthyroidism, will normally have much lower than normal levels of TSH in their blood, because the pituitary will stop trying to stimulate a thyroid gland that is already too active. These patients are likely to have high levels of T3 and T4.
What Is Normal?
Even with blood test results, though, thyroid disorders can sometimes be difficult to diagnose. Tests of TSH and of T3 and T4 levels are only about thirty years old. Doctors are still trying to determine what levels of these hormones in the blood should be considered normal. For most laboratory blood tests, the normal range is determined by using the range that is found in a control group — a large group of people who are classified as normal. The average result from a person in that group is considered the middle of the normal range. Then labs analyze the statistics for the whole group to determine what the upper and lower ranges of normal are. This approach does not work well for thyroid disease, though, because thyroid disease is so common that many people in the control group actually had undiagnosed thyroid disorders. As a result, the blood tests were classifying some patients as normal even though they actually had hypothyroidism or hyperthyroidism. That is what happened to 54-year-old Mary, who later wrote about her experience:
My first symptoms…were depression and fatigue. Prozac overcame the depression but not the chronic tiredness.
Every doctor’s visit yielded a different diagnosis. Severe cramps and constipation were labeled diverticulosis….when my hair started falling out in clumps, the doctor said the cause was stress….after two emergency room visits, I was referred to a rheumologist, who promptly diagnosed rheumatoid arthritis….Only once did a doctor order a thyroid screening—after I mentioned having gained twenty pounds (from 105 to 125) in six months. The TSH was elevated according to today’s guidelines but at that time was considered “high normal.”
As Mary’s story shows, today the level of each thyroid hormone in the blood that is considered normal keeps changing as doctors work more with the test and develop a better understanding of thyroid disease. Doctors who specialize in thyroid disorders know this and are very careful in how they interpret blood test results, especially when the results are normal but still at the low or high end of the normal range.
More Tests
If initial blood test results are uncertain, or more testing is needed, a lab can also test the patient’s blood for antibodies that are produced by patients who have Hashimoto’s thyroiditis (the disease that is responsible for most hypothyroidism) or Graves’ disease (the disease that is responsible for most hyperthyroidism). Another option is to test the blood for other substances that are made by the thyroid gland. For example, the thyroid produces higher than usual levels of thyroglobulin when it is inflamed or injured, or when a patient has thyroid cancer. It produces higher levels of calcitonin, a hormone, when a nodule of a rare form of thyroid cancer (medullary thyroid cancer) has developed.
If blood tests are inconclusive, doctors can order other tests. One option is a radioactive iodine uptake scan. One of the thyroid’s jobs in the body is to collect and store iodine. If a patient takes a dose of radioactive iodine, the thyroid will collect it, and a few hours later, technicians can take a scan of the thyroid using a tool that measures radioactivity. The scan shows how much iodine was collected by the thyroid. A lower than normal uptake indicates that the thyroid is underactive, while a higher than normal uptake indicates a hyperactive thyroid.
In Mary’s case, above, doctors did not diagnose thyroid disorder on their own. Like many patients, Mary finally decided to take matters into her own hands. She gathered her medical records together, did her research, and concluded that she had hypothyroidism. Then she found a new doctor and demanded more tests. “Within three days,” Mary says, “I was diagnosed with hypothyroidism and received a prescription for thyroid hormone. I gradually discontinued my other medications, and within six months I felt like my old self, only better.”
Fortunately, thyroid disorders are relatively simple to treat once they have been diagnosed. Most patients can be treated with thyroid hormones. Like Mary, patients may have to be patient and give their bodies time to adjust to the changes in their hormone levels. After a few months, though, patients often find that they feel much better. Fatigue and mental fog lift, moods tend to improve, and the odd random symptoms such as constipation and hair loss start to clear up. Doctors who specialize in thyroid disorders often find it very satisfying to treat patients who have been trying for months or years to figure out what was wrong with them. Kenneth Ain, the director of the University of Kentucky Thyroid Clinic, explains that he became interested in the thyroid when he was a new intern working in the intensive care unit of a hospital. He writes,
As a new intern, my first intensive care patient was a comatose gentleman whose illness had defied understanding for three weeks. What a triumph for a new physician to diagnose myxedema (hypothyroid) coma and see my patient awaken after sufficient treatment with thyroid hormone!
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